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\u300e\u764c\u306e\u81e8\u5e8a\u300f\u300049\u5dfb11\u53f7\u3000\u76ee\u6b21<\/span><\/p>\n

\u3000\u3000\u7dcf\u3000\u8aac<\/strong><\/p>\n

\u764c\u5916\u79d1\u306e\u3042\u308a\u65b9\u3092\u3081\u3050\u3063\u3066\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u52a0\u85e4\u7d18\u4e4b\u30001399(1)<\/strong><\/p>\n

\u3000\u3000\u539f\u3000\u8457<\/strong><\/p>\n

\u982d\u9838\u90e8\u764c\u75c7\u4f8b\u306b\u304a\u3051\u308b\u91cd\u8907\u60aa\u6027\u816b\u760d\u306e\u81e8\u5e8a\u7684\u691c\u8a0e\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u4e95\u53e3\u5e83\u7fa9\u30fb\u4ed6\u30001411(13)<\/strong><\/p>\n

\u8853\u524d\u691c\u67fb\u306b\u3066\u98df\u9053\u6241\u5e73\u4e0a\u76ae\u764c\u3068\u8a3a\u65ad\u3055\u308c\u305f\u98df\u9053\u539f\u767a\u5c0f\u7d30\u80de\u764c\u306e\u5185\u8996\u93e1\u6240\u898b\u3068<\/strong><\/p>\n

\u3000\u3000\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u7279\u5fb4\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5c71\u672c\u7d14\u4e5f\u30fb\u4ed6\u30001417(19)<\/strong><\/p>\n

\u5927\u8178\u764c\u306b\u304a\u3051\u308bOrotate Phosphoribosyl Transferase(OPRT),Dihydropyrimidine<\/strong><\/p>\n

\u3000\u3000Dehydrogenase(DPD)\u6d3b\u6027\u306e\u95a2\u9023\u6027\u3068\u81e8\u5e8a\u75c5\u7406\u5b66\u7684\u56e0\u5b50\u306b\u95a2\u3059\u308b\u691c\u8a0e<\/strong><\/p>\n

\u3000\u3000\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u4e0a\u6751\u4f73\u592e\u30fb\u4ed6\u30001425(27)<\/strong><\/p>\n

\u8180\u80f1\u764c\u8a3a\u65ad\u306b\u304a\u3051\u308b\u5c3f\u4e2d\u816b\u760d\u30de\u30fc\u30ab\u30fc\u306e\u691c\u8a0e<\/strong><\/p>\n

\u3000\u3000\uff0d\u5c3f\u4e2dBFP,CYFRA21-1,BTA\u30c6\u30b9\u30c8\u304a\u3088\u3073\u5c3f\u7d30\u80de\u8a3a\uff0d\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6c60\u7530\u9f8d\u4ecb\u30fb\u4ed6\u30001431(33)<\/strong><\/p>\n

\u591a\u767a\u6027\u9aa8\u9ac4\u816b\u5256\u691c\u4f8b\u306b\u307f\u3089\u308c\u305f\u9aa8\u75c5\u5909\u306e\u75c5\u7406\u5b66\u7684\u691c\u8a0e<\/strong><\/p>\n

\u3000\u3000\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u68ee\u8107\u662d\u4ecb\u30fb\u4ed6\u30001437(39)<\/strong><\/p>\n

\u3000\u3000\u75c7\u3000\u4f8b<\/strong><\/p>\n

\u4f4e\u4fb5\u8972\u6cbb\u7642\u3067\u6839\u6cbb\u3057\u5f97\u305fstage \u2160\u9ad8\u9f62\u8005\u4e09\u91cd\u764c\u306e1\u4f8b\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u57ce\u6839\u61b2\u4e45\u30fb\u4ed6\u30001445(47)<\/strong><\/p>\n

5-fluorouracil+Nedaplatin(FNp)\u7642\u6cd5\u3068\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u306e\u540c\u6642\u4f75\u7528\u304c\u6709\u52b9\u3067\u3042\u3063\u305f<\/strong><\/p>\n

\u3000\u3000\u98df\u9053\u5c0f\u7d30\u80de\u764c\u306e1\u4f8b\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u83ca\u6c60\u7531\u5ba3\u30fb\u4ed6\u30001451(53)<\/strong><\/p>\n

\u30a2\u30eb\u30b4\u30f3\u30d7\u30e9\u30ba\u30de\u51dd\u56fa\u6cd5\u304a\u3088\u3073\u816b\u760d\u5185\u5c40\u6ce8\u6cd5\u306b\u3088\u308a\u8457\u52b9\u3092\u8a8d\u3081\u305f2\u578b\u80c3\u764c\u306e1\u4f8b<\/strong><\/p>\n

\u3000\u3000\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u852d\u539f\u805e\u5929\u30fb\u4ed6\u30001457(59)<\/strong><\/p>\n

\u5f53\u79d1\u306b\u304a\u3051\u308bFamilial adenomatous polyposis\u306b\u5bfe\u3059\u308b\u8179\u8154\u93e1\u88dc\u52a9\u4e0b\u5927\u8178<\/strong><\/p>\n

\u3000\u3000\u4e9c\u5168\u6458\u8853\u306b\u3064\u3044\u3066\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u95a2\u5ddd\u6d69\u53f8\u30fb\u4ed6\u30001463(65)<\/strong><\/p>\n

\u598a\u5a20\u306b\u5408\u4f75\u3057\u5065\u5150\u3092\u5f97\u305f\u5b50\u5bae\u9838\u90e8\u985e\u5185\u819c\u817a\u764c\u306e1\u4f8b\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u7686\u5ddd\u5e78\u4e45\u30fb\u4ed6\u30001469(71)<\/strong><\/p>\n

\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u5b9f\u5730\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3000NCCN2003\u5e74\u7248\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u20261477(79)<\/strong><\/p>\n

\u3000\u3000\u9023\u3000\u8f09<\/strong><\/p>\n

\u8a3a\u65ad\u30fb\u6cbb\u7642\u6280\u8853\u8b1b\u5ea7<\/strong><\/p>\n

\u3000\u3000PTBD\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5b87\u91ce\u8015\u6cbb\u30fb\u4ed6\u30001473(75)<\/strong><\/p>\n

\u4e16\u754c\u306e\u7a93\u307813\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u20261499(101)<\/strong><\/p>\n

\u4e16\u754c\u306e\u7a93\u304b\u3089\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u20261505(107)<\/strong><\/p>\n

\u3000\u3000\u304c\u3093\u30fb\u30a2\u30ca\u30a6\u30f3\u30b9\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u6803\u6728\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u30ec\u30b8\u30c7\u30f3\u30c8\u52df\u96c6\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u20261416(18)<\/strong><\/p>\n

\u30b2\u30ce\u30e0\u5275\u85ac\u79d1\u5b66\u30fb\u85ac\u7406\u30b2\u30ce\u30df\u30af\u30b9\u5927\u5b66\u9662\u751f(\u533b\u79d1\u5b66\u4fee\u58eb\u30fb\u535a\u58eb\u8ab2\u7a0b)\u52df\u96c6\u2026\u2026\u2026\u2026\u2026\u2026\u20261430(32)<\/strong><\/p>\n

\u8ca1\u56e3\u6cd5\u4eba\u764c\u7814\u7a76\u4f1a\u9644\u5c5e\u75c5\u9662\u30ec\u30b8\u30c7\u30f3\u30c8,\u30b7\u30cb\u30a2\u30ec\u30b8\u30c7\u30f3\u30c8\u52df\u96c6<\/strong><\/p>\n

\u3000\u3000\uff0d\u5e73\u621016\u5e74\u5ea6\u52df\u96c6\u8981\u9805\uff0d\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u20261456(58)<\/strong><\/p>\n

\u7b2c10\u56de\u611b\u77e5\u770c\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u56fd\u969b\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u20261468(70)<\/strong><\/p>\n

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