{"id":5024,"date":"2024-08-06T15:42:41","date_gmt":"2024-08-06T06:42:41","guid":{"rendered":"https:\/\/shinoharashinsha.co.jp\/?page_id=5024"},"modified":"2024-08-06T15:43:02","modified_gmt":"2024-08-06T06:43:02","slug":"vol-46-no-3-2000-3","status":"publish","type":"page","link":"https:\/\/shinoharashinsha.co.jp\/?page_id=5024","title":{"rendered":"Vol.46  No.3 2000. 3"},"content":{"rendered":"<p><span style=\"font-size: 300%;\">Vol.46 No.3 2000. 3<\/span><\/p>\n<p><strong>\u7279\u96c6<\/strong><\/p>\n<p><strong>\u65e5\u672c\u533b\u5b66\u653e\u5c04\u7dda\u5b66\u4f1a\u751f\u7269\u90e8\u4f1a \u7b2c 29 \u56de\u653e\u5c04\u7dda\u306b\u3088\u308b\u5236\u764c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/strong><\/p>\n<p><strong>21 \u4e16\u7d00\u306b\u5411\u3051\u3066\u306e\u653e\u5c04\u7dda\u6cbb\u7642\uff1a\u57fa\u790e\u306b\u671b\u3080\u3082\u306e\uff0c\u81e8\u5e8a\u306b\u671f\u5f85\u3059\u308b\u3082\u306e<\/strong><\/p>\n<p><strong>\u5e8f\u6587\u2026\u677e\u539f\u5347\u2026177\uff081\uff09<\/strong><\/p>\n<p><strong>\u30bb\u30c3\u30b7\u30e7\u30f3 1 .\u91cd\u7c92\u5b50\u7dda\u6cbb\u7642\u306b\u671b\u3080\u3082\u306e<\/strong><\/p>\n<p><strong>\u57fa\u790e<\/strong><\/p>\n<p><strong>\u91cd\u7c92\u5b50\u7dda\u6cbb\u7642\u306e\u7269\u7406\u7684\u57fa\u790e\u2026\u91d1\u4e95\u9054\u660e\u2026179\uff083\uff09<\/strong><\/p>\n<p><strong>\u91cd\u7c92\u5b50\u7dda\u306e\u9178\u7d20\u52b9\u679c\u3068\u816b\u760d\u518d\u9178\u7d20\u5316\u2026\u5b89\u85e4\u8208\u4e00\u2026184\uff088\uff09<\/strong><\/p>\n<p><strong>\u70ad\u7d20\u7dda\u5206\u5272\u7167\u5c04\u306e\u6b63\u5e38\u7d44\u7e54\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u2026\u963f\u90e8\u7531\u76f4\u30fb\u4ed6\u2026188\uff0812\uff09<\/strong><\/p>\n<p><strong>\u81e8\u5e8a<\/strong><\/p>\n<p><strong>\u91cd\u7c92\u5b50\u7dda\u6cbb\u7642\u306b\u671b\u3080\u3053\u3068\u2015 X \u7dda\u6cbb\u7642\u306e\u7acb\u5834\u304b\u3089\u2015\u2026\u897f\u5c3e\u6b63\u9053\u30fb\u4ed6\u2026192\uff0816\uff09<\/strong><\/p>\n<p><strong>\u4e2d\u6027\u5b50\u7dda\u6cbb\u7642\u2026\u5c0f\u91ce\u516c\u4e8c\u30fb\u4ed6\u2026196\uff0820\uff09<\/strong><\/p>\n<p><strong>\u91cd\u7c92\u5b50\u7dda\u6cbb\u7642\u306b\u671b\u3080\u3053\u3068\u2015\u967d\u5b50\u7dda\u6cbb\u7642\u306e\u7acb\u5834\u304b\u3089\u2015\u2026\u79cb\u6839\u5eb7\u4e4b\u2026200\uff0824\uff09<\/strong><\/p>\n<p><strong>\u91cd\u7c92\u5b50\u7dda\u6cbb\u7642\u306e\u7acb\u5834\u304b\u3089\u2026\u6e9d\u6c5f\u7d14\u60a6\u30fb\u4ed6\u2026204\uff0828\uff09<\/strong><\/p>\n<p><strong>\u7279\u5225\u767a\u8a00<\/strong><\/p>\n<p><strong>\u7c92\u5b50\u7dda\u6cbb\u7642\u306e\u5c55\u671b\u2026\u5742\u672c\u6f84\u5f66\u2026208\uff0832\uff09<\/strong><\/p>\n<p><strong>\u30bb\u30c3\u30b7\u30e7\u30f3 2 .\u653e\u5c04\u7dda\u6cbb\u7642\u52b9\u679c\u306e\u5206\u5b50\u30ec\u30d9\u30eb\u304b\u3089\u306e\u691c\u8a0e<\/strong><\/p>\n<p><strong>\u57fa\u790e<\/strong><\/p>\n<p><strong>\u5148\u884c\u6307\u6a19\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9\u30c8\u30e9\u30c6\u30b8\u30fc<\/strong><\/p>\n<p><strong>\u2015\u907a\u4f1d\u5b50\u6cbb\u7642\u3084\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u6cbb\u7642\u3068\u306e\u4f75\u7528\u2015\u2026\u5927\u897f\u6b66\u96c4\u2026211\uff0835\uff09<\/strong><\/p>\n<p><strong>\u81e8\u5e8a<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u62b5\u6297\u6027\u816b\u760d\u306b\u3064\u3044\u3066\u306e\u81e8\u5e8a\u7684\u7dcf\u8ad6\u2026\u4f0a\u6771\u4e45\u592b\u30fb\u4ed6\u2026215\uff0839\uff09<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306e\u81e8\u5e8a\u7684\u5de5\u592b\u2026\u7530\u4e2d\u826f\u660e\u30fb\u4ed6\u2026219\uff0843\uff09<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u611f\u53d7\u6027\u3068\u653e\u5c04\u7dda\u8a98\u767a\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e<\/strong><\/p>\n<p><strong>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cb\u2026\u4e09\u6a4b\u7d00\u592b\u30fb\u4ed6\u2026223\uff0847\uff09<\/strong><\/p>\n<p><strong>\u6307\u5b9a\u767a\u8a00<\/strong><\/p>\n<p><strong>\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u306e\u767a\u73fe\u3068\u653e\u5c04\u7dda\u62b5\u6297\u6027\u3068\u306e\u95a2\u4fc2\u2015 I \u578b\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u5897\u6b96\u56e0\u5b50<\/strong><\/p>\n<p><strong>\u30ec\u30bb\u30d7\u30bf\u30fc\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30e2\u30c7\u30eb\u304b\u3089\u306e\u8003\u5bdf\u2015\u2026\u4e09\u6d66\u96c5\u5f66\u30fb\u4ed6\u2026227\uff0851\uff09<\/strong><\/p>\n<p><strong>\u30bb\u30c3\u30b7\u30e7\u30f3 3 .\u8ee2\u79fb\u306b\u95a2\u3059\u308b\u57fa\u790e\u3068\u81e8\u5e8a<\/strong><\/p>\n<p><strong>\u57fa\u790e<\/strong><\/p>\n<p><strong>\u8ee2\u79fb\u6291\u5236\u4f5c\u7528\u3092\u6709\u3059\u308b\u4f4e\u9178\u7d20\u7d30\u80de\u653e\u5c04\u7dda\u5897\u611f\u5264\u3068 BRM\u2026\u732a\u4fe3\u6cf0\u5178\u30fb\u4ed6\u2026233\uff0857\uff09<\/strong><\/p>\n<p><strong>\u6297\u8ee2\u79fb\u85ac\u306e\u958b\u767a\u72b6\u6cc1\u2026\u5c0f\u6797\u77e5\u96c4\u2026237\uff0861\uff09<\/strong><\/p>\n<p><strong>\u81e8\u5e8a\uff08\u8ee2\u79fb\u5236\u5fa1\u3068\u653e\u5c04\u7dda\u6cbb\u7642\uff09<\/strong><\/p>\n<p><strong>\u8ee2\u79fb\u5236\u5fa1\u3068\u653e\u5c04\u7dda\u6cbb\u7642\uff1a\u80ba\u764c\u2026\u829d\u672c\u96c4\u592a\u2026241\uff0865\uff09<\/strong><\/p>\n<p><strong>\u98df\u9053\u764c\u306e\u30ea\u30f3\u30d1\u7bc0\u8ee2\u79fb\u306b\u5bfe\u3059\u308b\u4e88\u9632\u7684\u7167\u5c04\u2026\u842c\u3000\u7be4\u61b2\u30fb\u4ed6\u2026244\uff0868\uff09<\/strong><\/p>\n<p><strong>\u8ee2\u79fb\u5236\u5fa1\u3068\u653e\u5c04\u7dda\u6cbb\u7642:\u524d\u7acb\u817a\u764c\u2026\u6c60\u7530\u3000\u6062\u30fb\u4ed6\u2026247\uff0871\uff09<\/strong><\/p>\n<p><strong>\u5b50\u5bae\u9838\u764c\u2026\u5742\u7530\u8015\u4e00\u30fb\u4ed6\u2026251\uff0875\uff09<\/strong><\/p>\n<p><strong>\u6307\u5b9a\u767a\u8a00<\/strong><\/p>\n<p><strong>MUC1 \u30e0\u30c1\u30f3\u5f37\u5236\u767a\u73fe\u30d2\u30c8\u814e\u764c\u7d30\u80de SN12C \u306e\u751f\u7269\u5b66\u7684\u6319\u52d5\u306b\u3064\u3044\u3066\u2026\u4f1d\u7530\u9999\u91cc\u30fb\u4ed6\u2026254\uff0878\uff09<\/strong><\/p>\n<p><strong>\u7279\u5225\u767a\u8a00<\/strong><\/p>\n<p><strong>\u8ee2\u79fb\u5de3\u306b\u5bfe\u3059\u308b\u653e\u5c04\u7dda\u6cbb\u7642\u6cd5\u2015\u305d\u306e\u554f\u984c\u70b9\u3068\u4eca\u5f8c\u306e\u5c55\u958b\u2015\u2026\u6e21\u8fba\u5bdb\u2026258\uff0882\uff09<\/strong><\/p>\n<p><strong>\u30bb\u30c3\u30b7\u30e7\u30f3 4 . Chemoradiotherapy<\/strong><\/p>\n<p><strong>\u57fa\u790e<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u3068\u5316\u5b66\u7642\u6cd5\u5264\u306e\u76f8\u4e92\u4f5c\u7528\u2026\u5c3e\u4e0b\u6587\u6d69\u2026263\uff0887\uff09<\/strong><\/p>\n<p><strong>Wortmannin \u306b\u3088\u308b\u653e\u5c04\u7dda\u5897\u611f\u306b\u304a\u3051\u308b\u816b\u760d\u5185\u5fae\u5c0f\u74b0\u5883\u56e0\u5b50\u306e\u5f71\u97ff\u2026\u7aaa\u7530\u5b9c\u592b\u30fb\u4ed6\u2026266\uff0890\uff09<\/strong><\/p>\n<p><strong>\u81e8\u5e8a<\/strong><\/p>\n<p><strong>\u8033\u9f3b\u54bd\u5589\u79d1\u306e\u7acb\u5834\u304b\u3089\u2026\u4f43\u3000\u3000\u5b88\u2026269\uff0893\uff09<\/strong><\/p>\n<p><strong>\u5316\u5b66\u653e\u5c04\u7dda\u7642\u6cd5\uff1aNeoadjuvant Chemotherapy versus Concurrent Chemotherapy\u2026\u897f\u6751\u606d\u660c\u2026273\uff0897\uff09<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u5316\u5b66\u7642\u6cd5\u4f75\u7528\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u2026\u5c71\u7530\u7ae0\u543e\u30fb\u4ed6\u2026278\uff08102\uff09<\/strong><\/p>\n<p><strong>\u80ba\u764c\u306b\u5bfe\u3059\u308b\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u306e\u73fe\u72b6\u2015\u5185\u79d1\u306e\u7acb\u5834\u304b\u3089\u2015\u2026\u677e\u7530\u5c1a\u4e45\u30fb\u4ed6\u2026282\uff08106\uff09<\/strong><\/p>\n<p><strong>\u6307\u5b9a\u767a\u8a00<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u5316\u5b66\u7642\u6cd5\u3092\u751f\u7269\u5b66\u7684\u898b\u5730\u304b\u3089\u898b\u308b\u3068\u2026\u9152\u4e95\u4e00\u592b\u2026286\uff08110\uff09<\/strong><\/p>\n<p><strong>\u30bb\u30c3\u30b7\u30e7\u30f3 5 .Response modifier<\/strong><\/p>\n<p><strong>5\u2015FU \u306e Biochemical modulation \u306e\u7406\u8ad6\u3068\u305d\u306e\u5fdc\u7528\u2026\u767d\u5742\u54f2\u5f66\u30fb\u4ed6\u2026291\uff08115\uff09<\/strong><\/p>\n<p><strong>\u764c\u6cbb\u7642\u306b\u304a\u3051\u308b BRM \u306e\u5f79\u5272\u2026\u5c71\u53e3\u4f73\u4e4b\u30fb\u4ed6\u2026297\uff08121\uff09<\/strong><\/p>\n<p><strong>\u4f4e\u9178\u7d20\u6027\u7d30\u80de\u5897\u611f\u5264\u306e\u73fe\u72b6\u2026\u6751\u5c71\u5343\u6075\u5b50\u2026301\uff08125\uff09<\/strong><\/p>\n<p><strong>\u6e29\u71b1\u6cbb\u7642\uff1a\u6700\u8fd1\u306e\u9032\u6b69\u2026\u5e73\u5ca1\u771e\u5bdb\u30fb\u4ed6\u2026306\uff08130\uff09<\/strong><\/p>\n<p><strong>\u982d\u9838\u90e8\u816b\u760d\u306b\u304a\u3051\u308b\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u540c\u6642\u4f75\u7528\u5316\u5b66\u7642\u6cd5\u306e\u6709\u7528\u6027\u306b\u3064\u3044\u3066\u2026\u559c\u591a\u307f\u3069\u308a\u2026309\uff08133\uff09<\/strong><\/p>\n<p><strong>\u6307\u5b9a\u767a\u8a00<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u3068\u6f22\u65b9\u2026\u7af9\u5ddd\u4f73\u5b8f\u30fb\u4ed6\u2026313\uff08137\uff09<\/strong><\/p>\n<p><strong>\u7279\u5225\u767a\u8a00<\/strong><\/p>\n<p><strong>\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c28\u5e74\u3092\u7d4c\u904e\u3057\u305f\u5de6\u4e2d\u8033\u7c98\u6db2\u8edf\u9aa8\u8089\u816b\u306e\uff11\u4f8b\u2026\u4e95\u4e0a\u4fca\u5f66\u30fb\u4ed6\u2026318\uff08142\uff09<\/strong><\/p>\n<p><strong>\u7279\u5225\u8b1b\u6f14<\/strong><\/p>\n<p><strong>\u67d3\u8272\u4f53\u5de5\u5b66\u3092\u7528\u3044\u305f\u7d30\u80de\u306e\u653e\u5c04\u7dda\u611f\u53d7\u6027\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u7fa4\u306e\u540c\u5b9a\u2026\u6817\u653f\u660e\u5f18\u30fb\u4ed6\u2026321\uff08145\uff09<\/strong><\/p>\n<p><strong>\u6559\u80b2\u8b1b\u6f14<\/strong><\/p>\n<p><strong>\u5c0f\u7dda\u6e90\u6cbb\u7642\u2026\u6e0b\u8c37\u5747\u30fb\u4ed6\u2026330\uff08154\uff09<\/strong><\/p>\n<p><strong>\u304c\u3093\u30fb\u30a2\u30ca\u30a6\u30f3\u30b9\u30e1\u30f3\u30c8<\/strong><\/p>\n<p><strong>\u7b2c18\u56de\u65e5\u672c\u30d2\u30c8\u7d30\u80de\u5b66\u4f1a\u2026231\uff0855\uff09<\/strong><\/p>\n<p><strong>\u7b2c10\u56de\u65e5\u672c\u4e73\u764c\u691c\u8a3a\u5b66\u4f1a\u7dcf\u4f1a\u306e\u3054\u6848\u5185\u2026232\uff0856\uff09<\/strong><\/p>\n<p><strong>\u7b2c38\u56de\u65e5\u672c\u764c\u6cbb\u7642\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u6f14\u984c\u52df\u96c6\u306e\u3054\u6848\u5185\u2026236\uff0860\uff09<\/strong><\/p>\n<p><strong>\u7b2c12\u56de BACT\uff08Biological Approaches to Cancer Treatment\uff09\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u2026262\uff0886\uff09<\/strong><\/p>\n<p><a href=\"https:\/\/shinoharashinsha.co.jp\/?page_id=1079\">\u300c\u764c\u306e\u81e8\u5e8a\u300d\u3078\u623b\u308b<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Vol.46 No.3 2000. 3 \u7279\u96c6 \u65e5\u672c\u533b\u5b66\u653e\u5c04\u7dda\u5b66\u4f1a\u751f\u7269\u90e8\u4f1a \u7b2c 29 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