{"id":5364,"date":"2024-08-26T16:19:00","date_gmt":"2024-08-26T07:19:00","guid":{"rendered":"https:\/\/shinoharashinsha.co.jp\/?page_id=5364"},"modified":"2024-08-26T16:46:18","modified_gmt":"2024-08-26T07:46:18","slug":"%e4%b9%b3%e7%99%8c%e3%81%ae%e8%87%a8%e5%ba%8avol-25-no-6","status":"publish","type":"page","link":"https:\/\/shinoharashinsha.co.jp\/?page_id=5364","title":{"rendered":"\u4e73\u764c\u306e\u81e8\u5e8aVol.25 No.6"},"content":{"rendered":"\n

\u4e73\u764c\u306e\u81e8\u5e8aVol.25 No.6<\/font><\/p>\n\n\n\n

\u76ee\u6b21
\u7279\u96c6\u3000\u4e73\u764c\u306e\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u3068\u81e8\u5e8a\u30fc\u8a3a\u65ad\u3068\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u30fc(2)
DNA\u640d\u50b7\u5fdc\u7b54\u3068\u4e73\u764c\u306e\u85ac\u5264\u611f\u53d7\u6027<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u592a\u7530\u667a\u5f66<\/strong>
\uff08\u8056\u30de\u30ea\u30a2\u30f3\u30ca\u533b\u79d1\u5927\u5b66\u5927\u5b66\u9662 \u533b\u5b66\u7814\u7a76\u79d1\u30fb\u5fdc\u7528\u5206\u5b50\u816b\u760d\u5b66\uff09\u30fb\u4ed6\u3000609(5)<\/strong><\/p>\n\n\n\n

\u4e73\u764c\u306b\u304a\u3051\u308bRb\u4e0d\u6d3b\u5316\u3068\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\u306b\u3064\u3044\u3066
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6709\u99ac\u597d\u7f8e<\/strong>
\uff08\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u533b\u5b66\u90e8 \u5148\u7aef\u533b\u79d1\u5b66\u7814\u7a76\u6240 \u907a\u4f1d\u5b50\u5236\u5fa1\u7814\u7a76\u90e8\u9580\uff09\u30fb\u4ed6\u3000617(13)<\/strong><\/p>\n\n\n\n

\u30d3\u30b9\u30db\u30b9\u30db\u30f3\u9178\u306b\u3088\u308b\u03b3\u03b4\u578bT\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u4e73\u764c\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6749\u6c5f\u77e5\u6cbb\uff08\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662 \u533b\u5b66\u7814\u7a76\u79d1 \u4e73\u817a\u5916\u79d1\uff09\u30fb\u4ed6\u3000623(19)<\/strong><\/p>\n\n\n\n

\u3042\u3068\u304c\u304d\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5ca9\u702c\u5f18\u656c<\/strong>
\uff08\u718a\u672c\u5927\u5b66\u5927\u5b66\u9662 \u751f\u547d\u79d1\u5b66\u7814\u7a76\u90e8 \u4e73\u817a\u30fb\u5185\u5206\u6ccc\u5916\u79d1\uff09\u3000631(27)<\/strong><\/p>\n\n\n\n

\u8b1b\u5ea7<\/strong>
\u907a\u4f1d\u6027\u4e73\u764c\u2464
\u907a\u4f1d\u6027\u4e73\u764c,\u5375\u5de3\u764c\u306b\u5bfe\u3059\u308b\u6226\u7565<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u00b7\u5c71\u5185\u82f1\u5b50\uff08\u8056\u8def\u52a0\u56fd\u969b\u75c5\u9662 \u4e73\u817a\u5916\u79d1\uff09\u30fb\u4ed6\u3000633(29)<\/strong><\/p>\n\n\n\n

\u539f\u8457<\/strong>
\u30eb\u30fc\u30c1\u30f3\u30de\u30f3\u30e2\u30b0\u30e9\u30d5\u30a3\u304a\u3088\u3073\u4e73\u623f\u8d85\u97f3\u6ce2\u3067\u6307\u6458\u3067\u304d\u305a,MR\u30de\u30f3\u30e2\u30b0\u30e9\u30d5\u30a3\u3067\u6307\u6458\u3055\u308c\u305f\u4e73\u764c<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5c71\u672c\u5f25\u751f\uff08\u764c\u7814\u6709\u660e\u75c5\u9662 \u753b\u50cf\u8a3a\u65ad\u90e8\uff09\u30fb\u4ed6\u3000639(35)<\/strong><\/p>\n\n\n\n

HER2\u967d\u6027\u9032\u884c\u518d\u767a\u4e73\u764c\u306b\u5bfe\u3059\u308bLapatinib\u6295\u4e0e\u5f8c\u306eTrastuzumab\u518d\u6295\u4e0e\u306e\u691c\u8a0e
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6797\u88d5\u502b\uff08\u611b\u77e5\u770c\u304c\u3093\u30bb\u30f3\u30bf\u30fc \u4e2d\u592e\u75c5\u9662 \u4e73\u817a\u79d1\uff09\u30fb\u4ed6\u3000645(41)<\/strong><\/p>\n\n\n\n

\u30de\u30f3\u30e2\u30b0\u30e9\u30d5\u30a3\u30fb\u8d85\u97f3\u6ce2\u540c\u6642\u4f75\u7528\u691c\u8a3a\u306b\u304a\u3051\u308b\u9069\u5207\u306a\u7cbe\u67fb\u57fa\u6e96\u306e\u691c\u8a0e
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5742\u4f73\u5948\u5b50<\/strong>
\uff08\u8ca1\u56e3\u6cd5\u4eba \u6771\u4eac\u90fd\u4e88\u9632\u533b\u5b66\u5354\u4f1a\/\u5e02\u30f6\u8c37\u4e73\u817a\u8aad\u5f71\u59d4\u54e1\u4f1a\uff09\u30fb\u4ed6\u3000649(45)<\/strong><\/p>\n\n\n\n

\u75c7\u4f8b
\u4e73\u817ainvasive micropapillary carcinoma\u306e1\u5207\u9664\u4f8b
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6c38\u7530\u597d\u9999\uff08\u7523\u696d\u533b\u79d1\u5927\u5b66 \u7b2c\u4e8c\u5916\u79d1\uff09\u30fb\u4ed6\u3000659(55)<\/strong><\/p>\n\n\n\n

\u91dd\u751f\u691c\u3067\u8a3a\u65ad\u3057,\u30b9\u30c6\u30ed\u30a4\u30c9\u5185\u670d\u3067\u5b8c\u6cbb\u3057\u305f\u8089\u82bd\u816b\u6027\u4e73\u817a\u708e\u306e1\u4f8b
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5ca9\u8c37\u80e4\u751f\uff08\u864e\u306e\u9580\u75c5\u9662 \u4e73\u817a\u30fb\u5185\u5206\u6ccc\u5916\u79d1\uff09\u30fb\u4ed6\u3000665(61)<\/strong><\/p>\n\n\n\n

BD \u9818\u57df\u306e\u4e73\u623f\u6e29\u5b58\u8853\u306b\u304a\u3044\u3066\u8179\u90e8\u771f\u76ae\u8102\u80aa\u5f01\u6319\u4e0a\u306b\u3088\u308b\u518d\u5efa\u3092\u884c\u3063\u305f1\u4f8b
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u690d\u5f18\u5948\u6d25\u6075\uff08\u764c\u7814\u6709\u660e\u75c5\u9662 \u4e73\u817a\u30bb\u30f3\u30bf\u30fc \u5916\u79d1\uff09\u30fb\u4ed6\u3000671 (67)<\/strong><\/p>\n\n\n\n

\u30d3\u30b9\u30d5\u30a9\u30b9\u30d5\u30a9\u30cd\u30fc\u30c8\u7cfb\u85ac\u5264\u6295\u4e0e\u3068\u95a2\u9023\u3057\u305f\u984e\u9aa8\u58ca\u6b7b\u30fc\u4e73\u764c\u9aa8\u8ee2\u79fb\u75c7\u4f8b\u306b\u3064\u3044\u3066\u30fc<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6709\u5409\u9756\u5247<\/strong>
\uff08\u5927\u962a\u533b\u79d1\u5927\u5b66 \u611f\u899a\u5668\u6a5f\u80fd\u5f62\u614b\u533b\u5b66\u8b1b\u5ea7 \u53e3\u8154\u5916\u79d1\u5b66\u6559\u5ba4\uff09\u30fb\u4ed6\u3000677(73)<\/strong><\/p>\n\n\n\n

\u7de8\u96c6\u9867\u554f\uff1d\u83c5\u91ce\u6674\u592b\uff0f\u68ee\u4e98\uff0f\u963f\u90e8\u4ee4\u5f66\uff0f\u59b9\u5c3e\u4e98\u660e\uff0f\u6cc9\u96c4\u52dd\uff0f\u5c0f\u5c71\u535a\u8a18\uff0f\u7530\u5cf6\u77e5\u90ce\uff0f\u5742\u5143\u543e\u5049
\u7de8\u96c6\u59d4\u54e1\uff1d\u79cb\u5c71\u592a\uff0f\u4f0a\u85e4\u826f\u5247\uff0f\u5ca9\u702c\u62d3\u58eb\uff0f\u6885\u6751\u3057\u306e\u3076\uff0f\u971e\u5bcc\u58eb\u96c4\uff0f\u5712\u5c3e\u535a\u53f8\uff0f\u89d2\u7530\u535a\u5b50\uff0f\u4e2d\u6751\u6e05\u543e<\/strong><\/p>\n\n\n\n

\u77f3\u7070\u4e73\u77f3\u7070\u5316\u3092\u5448\u3057\u305f\u975e\u6d78\u6f64\u6027\u4e73\u7ba1\u764c\u306e1\u4f8b<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5c0f\u5009\u85ab\uff08 \u764c\u7814\u7a76\u4f1a\u764c\u7814\u7a76\u6240 \u75c5\u7406\u90e8\uff09\u30fb\u4ed6\u3000685(81)<\/strong><\/p>\n\n\n\n

\u4e73\u817a\u539f\u767a\u975e\u6d78\u6f64\u6027\u795e\u7d4c\u5185\u5206\u6ccc\u764c\u306e1\u4f8b
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5927\u5834\u5d07\u65e6<\/strong>
\uff08\u9577\u91ce\u770c\u539a\u751f\u9023\u9577\u91ce\u677e\u4ee3\u7dcf\u5408\u75c5\u9662 \u4e73\u817a\u5185\u5206\u6ccc\u5916\u79d1\uff09\u30fb\u4ed6\u3000691 (87)<\/strong><\/p>\n\n\n\n

\u4e73\u764c\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306b\u3088\u308a\u75c5\u7406\u5b66\u7684\u5b8c\u5168\u594f\u52b9\u4f8b\u306b\u304a\u3051\u308b\u65e9\u671f\u4e2d\u67a2\u795e\u7d4c\u518d\u767a<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u5409\u7530\uff08\u5ca9\ufa11\uff09\u73b2\u5b50<\/strong>
\uff08\u764c\u7814\u7a76\u4f1a\u6709\u660e\u75c5\u9662 \u4e73\u817a\u30bb\u30f3\u30bf\u30fc \u5916\u79d1\uff09\u30fb\u4ed6\u3000699(95)<\/strong><\/p>\n\n\n\n

\u4e73\u817a\u817a\u7b4b\u4e0a\u76ae\u816b\u306e1\u4f8b\u30fc\u753b\u50cf\u6240\u898b\u3068\u75c5\u7406\u7d44\u7e54\u50cf\u3092\u5bfe\u6bd4\u3057\u3066\u30fc
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u52a0\u5965\u7bc0\u5b50\uff08\u4eac\u90fd\u30d6\u30ec\u30b9\u30c8\u30bb\u30f3\u30bf\u30fc \u6ca2\u4e95\u8a3a\u7642\u6240\uff09\u30fb\u4ed6\u3000705(101)<\/strong><\/p>\n\n\n\n

\u5b66\u4f1a\u30c8\u30d4\u30c3\u30af\u30b9<\/strong>
\u30e9\u30d1\u30c1\u30cb\u30d6\u6295\u4e0e\u4e2d\u60a3\u8005\u306e\u76ae\u819a\u969c\u5bb3\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u3068\u770b\u8b77\u306e\u691c\u8a0e
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6238\u7551\u5229\u9999\uff08\u76f8\u826f\u75c5\u9662 \u770b\u8b77\u90e8\uff09\u30fb\u4ed6\u3000712(108)<\/strong><\/p>\n\n\n\n

\u4e73\u764c\u5316\u5b66\u7642\u6cd5\u3092\u5b89\u5168\u306b\u884c\u3046\u305f\u3081\u306e\u5916\u6765\u770b\u8b77\u30b7\u30b9\u30c6\u30e0
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u9752\u6728\u5bcc\u58eb\u5b50\uff08\u764c\u7814\u7a76\u4f1a\u6709\u660e\u75c5\u9662 \u4e73\u817a\u30bb\u30f3\u30bf\u30fc\uff09\u30fb\u4ed6\u3000714(110)<\/strong><\/p>\n\n\n\n

\u8853\u4e2dICG\uff08\u30a4\u30f3\u30c9\u30b7\u30a2\u30cb\u30f3\u30b0\u30ea\u30fc\u30f3\uff09\u9020\u5f71\u306b\u3088\u308b\u904a\u96e2\u8179\u76f4\u7b4b\u76ae\u5f01\u751f\u7740\u9818\u57df\u306e\u691c\u8a0e<\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u6b66\u77f3\u660e\u7cbe<\/strong>\uff08\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u67cf\u75c5\u9662 \u5f62\u6210\u5916\u79d1\uff09\u3000716(112) <\/strong><\/p>\n\n\n\n

\u7d44\u63db\u3048\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc\u88fd\u5264\u306b\u3088\u308b\u816b\u760d\u9078\u629e\u7684\u6cbb\u7642\u30fc\u7c73\u56fd\u306b\u304a\u3051\u308bphase I study\u30fc <\/strong>
\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u85e4\u68ee\u5b9f\uff08\u6771\u4eac\u533b\u79d1\u5927\u5b66\u8328\u57ce\u533b\u7642\u30bb\u30f3\u30bf\u30fc \u4e73\u817a\u79d1\uff09\u30fb\u4ed6\u3000718(114)<\/strong><\/p>\n\n\n\n

\u30bf\u30ad\u30b5\u30f3\u8d77\u56e0\u6027\u795e\u7d4c\u969c\u5bb3\u306e\u5bfe\u7b56\u30fc\u52a0\u5727\u6a5f\u80fd\u30b9\u30c8\u30c3\u30ad\u30f3\u30b0\u306b\u3088\u308b\u4e88\u9632\u52b9\u679c\u306e\u691c\u8a0e\u30fc
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